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Triple agonists with GLP1, GIP and glucagon Given the efficacy and benefits of the dual GLP-1/GIP RA tirzepatide and the dual GLP-1/glucagon RA, a triple agonist targeting all three receptors (GLP-1/GIP/glucagon) may result in superior WL and glycaemic control than dual agonists
However, both medications can independently affect gastrointestinal function, and overlapping side effects may create additional management considerations that warrant provider awareness and monitoring
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BPC-157 is particularly interesting in this context because of its origin in gastric juice and its demonstrated gut-healing properties
Gut Microbes 14:2102878
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