Recruitment of cBAF and PBAF complexes is required for transcription of SLC7A11 SLC7A11 To determine the mechanism underlying the attenuation of SLC7A11 mRNA expression in SWI/SNF-deficient cancer cells, we investigated the involvement of SMARCA4 (a component of cBAF, PBAF, and ncBAF) and SMARCB1 (a component of cBAF and PBAF) in transcriptional upregulation of SLC7A11
This distinction is particularly important for engineering because modifying downstream responsive genes often produce transient phenotypic effects, whereas manipulation of upstream regulatory hubs is more likely to generate coordinated and durable metabolic responses
"N-Acetylcysteine--a safe antidote for cysteine/glutathione deficiency." Curr Opin Pharmacol

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Dougan, S
Angewandte Chemie, 132 (49), 2241422421