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Michael Calore: And thank you all for listening

Kalaany and Sabatini had shown in NOD-SCID (non-obese diabetic, severe combined immunodeficient) mice that xenografted tumors with constitutive activation of AKT by either gains in PIK3CA or loss of PTEN are resistant against CR, and insensitive to insulin and IGF-1 treatment in vitro

Finally, there is growing concern regarding loss of fat-free mass (muscle) during GLP-1RA-induced weight loss, particularly in older adults or those with pre-existing sarcopenia or osteoporosis

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Liggi M, Murgia D, Civolani A, Demelia E, Sorbello O, Demelia L

From inflammation to sexual dysfunctions: a journey through diabetes, obesity, and metabolic syndrome