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The high cost of brand-name drugs is due to R&D, marketing, and patent protection
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In pancreatic cancer cells, oncogenic K-Ras maintains the nucleotide pool via the MAPK-dependent signaling pathway, leading to MYC upregulation, and the use of MEK inhibitors reduces the incorporation of glutamine-derived nitrogen into purine nucleotides 38
Against fungus, azoles, echinocandins and liposomal amphotericin B, besides their specific mode of action, also induce ROS in planktonic and biofilm cells (Delattin et al., The protection available for cells under oxidative stress comes from natural antioxidants and several antioxidant enzymes (Davies, 1997)
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The science isnt yet conclusive
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