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Indeed, the stronger relationship between elevated circulating homocysteine levels and atherothrombotic disease observed in retrospective case-controlled studies than in prospective studies might be explained by the younger average age of subjects sustaining a coronary event in retrospective studies (in the positive study by Wald et al (1998), see the age comparison between retrospective and prospective studies)

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Glutathione S-transferases attach GSH to selected electrophilic compounds, supporting their metabolism and transport from cells

This naturally occurring compound helps protect the body from oxidative stress, which can contribute to aging, inflammation and various chronic diseases