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Pan Y, Hui X, Hoo RLC, Ye D, Chan CYC, Feng T, et al

Information developed based on pharmacology of the individual peptides

Epithalon is a synthetic tetrapeptide (Ala-Glu-Asp-Gly) based on a naturally occurring short-chain bioregulatory peptide

The investigational immuno-oncology combination of efti and KEYTRUDA achieved an objective response rate (ORR) of 35.5% (11 of 31 evaluable patients) and a disease control rate (DCR) of 58.1%, according to RECIST 1.1, in 1L HNSCC patients whose tumors do not express PD-L1 (Combined Positive Score [CPS] 20 PD-L1 expression levels are approximately 20%, 30%, and 50% of the HNSCC patient population, respectively

Relative to comparators, the risk for any of the commonly used cardiovascular end points was estimated to be below 1.0, and for both MACE-4 and MACE-3 (myocardial infarction, stroke, and all-cause death), the upper bounds of the confidence interval calculated around the hazard ratio were decidedly 8.5 %

Among these, Peptide No.218 showed the strongest combined proliferative and signaling activation effects and was selected as the lead peptide