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Drug Interactions and Compatibility 11.1 Interaction with Oral Antidiabetic Medications Semaglutide may be co-administered with oral antidiabetic agents, yet pharmacodynamic interactions require careful calibration

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However, increased heart rate is a recognised adverse reaction, with clinical trials showing a mean increase of 1-4 beats per minute

Aim for a 20 to 30 gram protein snack within 30 to 60 minutes of feeling the drugs peak effect or before exercise, for example, Greek yogurt with a tablespoon of nuts, a hardboiled egg, and a whole grain cracker, or a protein shake diluted with water