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Zara Cosentino, commenting on the committee's composition, said that while disclosure requirements represent a positive transparency measure, the situation creates a structural problem "especially when the people who stand to gain from growing access are the ones making the decision." Attorneys at Orrick, analyzing the committee before the meeting, concluded that the most probable outcome was that PCAC would recommend inclusion for some or all of the seven peptides calling it "a significant departure from prior PCAC precedent." Their prediction was accurate to the letter

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Filingeri noted that this research study was designed to further examine changes in weight, body fat mass, and muscle mass in patients taking incretin medications. We found that, under close supervision and regular follow-up from an obesity medicine specialist, patients were able to lose fat mass with only a minimal decline in muscle mass. Alexandra Filingeri, DCN, RCN Filingeri pointed out that the results of this study cannot be generalized to patients receiving medication via telemedicine without routine body composition analysis, nor can they be generalized to in-person visits without utilizing body composition analysis

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Clinical trials included women up to age 75 with efficacy maintained across age groups