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[57] This activation reduces the production of reactive oxygen species (ROS) and mitigates endoplasmic reticulum (ER) stress

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53 Pancreatic and Hepatobiliary Events Pancreatitis and Pancreatic Disorders It has been suggested that GLP-1 RAs may influence pancreatic physiology through multiple mechanisms, including effects related to rapid weight loss and gallstone formation, which have been hypothesized to contribute indirectly to pancreatitis risk

Advertisement Clinically, GLP-1 receptor agonists and SGLT-2 inhibitors generally offer greater effects on weight reduction and blood glucose lowering compared with DPP-4 inhibitors

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Most people adapt well to this change, though some experience altered fat digestion