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The peptide mechanism works at fundamental levels of tissue repair and systemic regulation

That is far beyond the static subcutaneous examples on this page and shows why oral and injected amounts should not be treated as interchangeable

International Journal of Endocrinology vol

Dixon et al., 2007)

Regardless of its origin, vitamin D undergoes two steps: first, in the liver, it is hydroxylated by 25-hydroxylase (CYP2R1) to form 25-hydroxyvitamin D [25(OH)D], and subsequently, in the kidney, it is hydroxylated by 1-hydroxylase (CYP27B1) to generate the biologically active form, 1,25-dihydroxyvitamin D [1,25(OH)D] (6)