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Petersen, E.A., et al., High-frequency 10-kHz spinal cord stimulation provides long-term (24-month) improvements in diabetes-related pain and quality of life for patients with painful diabetic neuropathy

5.5 Osmotic adjustment and ion homeostasis, and metabolic coordination Drought and salinity impose combined osmotic and ionic stresses that disrupt cellular water balance, membrane selectivity, and metabolic coordination (Gillani et al., 2022

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Continuous, multi-month use is widely discouraged because of progressive insulin resistance, organ-growth concerns, and IGF-1 receptor desensitization

As well, the correct dose must be used