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Tyrosine hydroxylase is the critical enzyme in the synthesis of epinephrine, norepinephrine and dopamine, and tryptophan hydroxylase is the essential enzyme in the synthesis of serotonin

Nausea is most pronounced during the first few weeks of treatment or following dose increases

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Heterogeneity was high for this outcome as well ( I 2 = 75.7%)

They are not recommended for cosmetic purposes, pregnancy, or those with specific medical conditions like medullary thyroid cancer or pancreatitis

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