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It requires a more conservative prescribing approach as it is contraindicated for some groups, such as pregnant women, due to the teratogenic nature of topiramate

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The researchers found that for the treatment regimen estimand, the mean change from baseline in hemoglobin A1c concentration was 1.69, 1.86, and 1.94 percent with 4, 9, and 12 mg of retatrutide, respectively, versus 0.81 percent with placebo, resulting in estimated treatment differences of 0.88, 1.04, and 1.12 percent, respectively, versus placebo

Meghan Garcia-Webb, MD, of Weight Medicine MD starts off by reminding readers that results can vary by person: The pace of weight loss depends on a variety of factors, including how well a patient is tolerating the medication, their pre-existing conditions, and medications they are on, she explains

What side effects might I experience as my tirzepatide dose increases