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In turn, nausea is the main adverse event associated with GLP-1RAs class

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Detailed findings can be found in Supplementary Material S2

Losing lean mass lowers metabolic reserve and makes recovery from side effects slower

Underlying health conditions such as cardiovascular disease, diabetes complications, depression, or other chronic illnesses continue to affect sexual function regardless of tirzepatide treatment

Written by Mace Scott, MD Founder and Medical Director at Chronos Body Health & Wellness Focus: medical weight loss, hormone optimization, wellness medicine, aesthetics Updated: June 2026