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The impaired interaction decelerated the oxidative half-reaction and decreased the steady-state concentration of available glutathionylated enzyme for the rate-limiting turnover of GSH
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Effect of empagliflozin on erythropoietin levels, iron stores, and red blood cell morphology in patients with type 2 diabetes mellitus and coronary artery disease
[PubMed ID: 18373199]
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Furthermore, large scale epidemiological studies are needed that investigate the effects of GLP-1 receptor agonists on the risk of hyperkalemia in people with type 2 diabetes, with only a few small clinical studies suggesting plausible mechanisms for increased potassium excretion.2425 GLP-1 receptor agonists might lead to increased potassium secretion owing to enhancement in sodium delivery to the cortical collecting duct and altered tubular electronegativity.2526 Additionally, long term kidney preservation by SGLT-2 inhibitors or GLP-1 receptor agonists might contribute to reduced hyperkalemia risks
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