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The limiting dilution sphere formation assay showed that the cells that were treated 20 days earlier with the combination of sertraline and 6 Gy irradiation were intrinsically rewired and presented a decreased sphere formation efficiency, indicating a 3-fold reduction and loss of long-term self-renewal capacity ( p = 0.0061) (Fig
K., Odin, M
Managing expectations month by month Knowing what to expect month by month prevents the discouragement that leads to premature discontinuation
The dose-response analysis determined an ED of 242.9 mg/kg and a maximum efficacy (E max ) of 54%, based on 1-h post-administration values [71]
