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10.1093/brain/aws189 42 CignarellaF.FilipelloF.BollmanB.CantoniC.LoccaA.MikesellR.et al

Pros: One of the most extensively studied healing peptides in animal and in vitro models, with a broad published mechanistic literature Reported to have a favorable short-term tolerability profile in the limited human data available, with side effects typically mild and self-limiting Available in both injectable and oral research formulations, offering flexibility for different use cases Cons: No completed Phase 2 or Phase 3 human clinical trials exist

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Results: Homozygous individuals comprised 2 from family A, 2 from family D, and 3 from family DY

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Copper is an essential cofactor for many biochemical processes, and binding it to GHK creates a peptide-copper model for laboratory study