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found that GLP-1 can reduce oxidative stress in BV2 microglia by inhibiting the accumulation of intracellular ROS and release of nitric oxide (NO), as well as by increasing the expression of the antioxidant glutathione peroxidase 1 (GPx1) and superoxide dismutase 1 (SOD1) (184)

Supplementing with oral glutathione under conditions in which intracellular glutathione status is compromised can restore tissue glutathione and promote ROS metabolism, thereby mitigating tissue atrophy, according to a 2017 study published in the World Journal of Gastroenterology

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Standard protocols increase doses every four weeks