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Increasing muscle derived IGF-1 was found protective in mouse models of ALS 11 , and delivering IGF-1 in the CNS also led to increased survival 12,13

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Furthermore, the pFeSAN-based GSH detection system could resist the interferences of various metal ions, amino acids, and proteins, validating well anti-interference and specificity of the pFeSAN-based GSH detection system (Fig

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Unsurprisingly, most clinical trials with NAC have resulted in lack of therapeutic efficacy [12-16]

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