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A protective effect of GLP-1 agonists on blood vessels has been demonstrated, as evidenced by the reduction of non-fatal and fatal stroke incidence by 15% and 19%, respectively, in patients with T2DM treated with GLP-1 agonists [43]

Mar 2022;101:108912

Alternative repletion strategies have focused on oral administration of GSH precursors (e.g., cysteine and glycine supplementation 9 ), and intravenous administration of GSH, 10 which although promising, is invasive and inconvenient, and therefore unlikely to be a practical solution

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While type 1 often manifests as an autoimmune insulin deficiency during childhood, T2DM predominantly develops throughout life