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If youve been reading this newsletter, you know Ive written about the fact that OA patients on GLP-1 drugs report pain improvement long before any meaningful weight loss occurs

The neurological aspects of the disease are thought to arise from the accumulation of methylmalonyl- CoA due to the requirement of B 12 as a cofactor to the enzyme methylmalonyl-CoA mutase

therefore, no age-based dose adjustment is recommended [29, 37, 38]

The identified P values of associated were corrected for multiple testing using the BH method (adjusting for the number of cell populations)

PMID 35359227