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limma powers differential expression analyses for RNA-sequencing and microarray studies
doi:10.1146/annurev.bi.52.070183.003431 Mezzetti F, Vero L de, Giudici P (2014) Evolved Saccharomyces cerevisiae wine strains with enhanced glutathione production obtained by an evolution-based strategy
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GLP-1 acts primarily on the hypothalamic arcuate nucleus (POMC/NPY neurons) to regulate energy homeostasis and metabolic set-pointit's the 'background thermostat' for caloric balance
Further mechanistic studies showed that NNMTi increases intracellular NAD levels and activates the SIRT1 pathway by inhibiting NNMT, thereby suppressing the transcription of adipogenic genes and preventing the maturation of preadipocytes.This research provides a new perspective for understanding the molecular mechanism of adipocyte differentiation, confirms the key role of NNMTi in regulating adipogenesis, and lays a foundation for subsequent obesity intervention studies
PMCID: PMC12608207
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