How Do They Work Differently
Criteria for inclusion and exclusion This study incorporated only those investigations that fulfilled specific inclusion criteria: publications in the English language, studies involving subjects diagnosed with type 2 diabetes mellitus (T2D), randomized controlled trials (RCTs), interventions that compared the efficacy of SGLT-2 inhibitors or GLP-1 receptor agonists against placebo, and reports on major adverse cardiovascular events (MACE) or hospitalization for heart failure (HHF), as well as cardiovascular outcomes irrespective of baseline metformin usage
The study examined changes in depressive symptoms using the Patient Health Questionnaire-9 (PHQ-9) and assessed suicidal ideation and behavior using the Columbia Suicide Severity Rating Scale
For context, tirzepatide's data come from SURMOUNT (NEJM 2022) and SURMOUNT-OSA (NEJM 2024)
Examples include the following nutraceuticals: Black ginger extract In human studies, 6 Yoshino S, Awa R, Miyake Y, Fukuhara I, Sato H, Ashino T, Tomita S, Kuwahara H
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