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In these STEP trials, most participants experienced mild to moderate symptoms, with the incidence of severe side effects being 9.8% in the semaglutide treatment group and 6.4% in the placebo group
More serious concerns have been reported
Previous studies have demonstrated the cleavage of allylcarbamates 20 , propargyls 21,22 , or allenes 23
Larger vials exist, but the 5mg format reduces waste if a protocol needs to be adjusted mid-course, and it keeps reconstituted solution within its optimal stability window before a new vial is needed