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Determining the correct B12 dosage can be tricky, as the appropriate amount depends on factors such as age, the severity of deficiency, and any coexisting conditions

Piccinin MA et al

However, some transporters, including OATP1B1/3 and OAT3, demonstrated inhibition following treatment with GLP-1 RAs and a dual GLP-1/GIP RA in vitro, suggesting that the assessment of transporter-mediated DDI by GLP-1 RAs may be necessary (Table 3)

Critically, the glucagon component appeared to drive increased energy expenditure and enhanced hepatic lipid oxidation without negating the glucose-lowering benefits conferred by GLP-1 and GIP activity