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For severe cases, a bigger dose might be given first, followed by smaller doses later

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Considering again that the myogenic stem cell activator HGF is found in an ECM-bound state 19,20,21,22,26 and undergoes nitration of tyrosine residues (Y198 and Y250) with aging 32,32,62 and muscle disuse (Kuwakdo et al., 2025), the present in vivo experiments provide a robust platform showing the potential for LASSS that could efficiently reduce or delay the nitration-dysfunction of ECM-bound HGF under peroxynitrite-generating conditions

12,13,14 Such variability implies the existence of spatial interactions capable of amplifying or buffering ferroptotic injury

Effects of beta-carotene on oxidative stress in normal and diabetic rats