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Future studies will test semaglutide's cardiac mechanisms While the findings raise the possibility that semaglutide's cardiovascular benefits extend beyond its effects on weight loss, the authors stress that the underlying mechanisms remain unclear

For a broader look at common treatment reactions, see our GLP-1 side effects guide

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Effective transdermal delivery would require advanced technologies such as: Microneedle arrays : Tiny needles that create microscopic channels in the skin to facilitate drug absorption (these are minimally invasive devices rather than traditional patches) Chemical penetration enhancers : Substances that temporarily increase skin permeability Iontophoresis : Using electrical currents to drive charged molecules through the skin Nanoparticle formulations : Encapsulating drugs in carriers designed to cross skin barriers Several preclinical and early-stage studies have explored these approaches for GLP-1 delivery, with some promising results in laboratory and animal models