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Previous medications had typically produced 5-8% weight loss

By the late 1980s, it was clear that therapeutically using GLP-1 would require either modifying the molecule to last longer or finding another way to keep levels high

Ozempic is also approved to reduce the risk of major cardiovascular events like heart attack and stroke in adults with type 2 diabetes and known heart disease

Yamada T, Nakamura S, Demitsu T, Nakamura T, Iida E, Yoneda K, Fukuda S, Hashimoto T (2013) Paraneoplastic pemphigus mimicking toxic epidermal necrolysis associated with B-cell lymphoma

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Your GLP-1 receptors are well-adapted, but the additional receptor systems need introduction