semaglutide nash phase 3 2·4 mg once weekly in patients with non-alcoholic steatohepatitis-related cirrhosis: a randomised, placebo-controlled 2 trial Semaglutide, a GLP-1R agonist, is

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In the STEP and SURMOUNT trials for semaglutide and tirzepatide respectively, weight loss curves generally began to flatten between weeks 36 and 60, reflecting the physiological set point adaptation that occurs as appetite suppression becomes partially offset by metabolic adaptation

On the positive side, behavioral changes will work with the drug to effect changes much faster

However, even high doses of exogenous GIP do not lead to a rise in GLP-1 concentrations in human participants with [38] and without [38, 39] type 2 diabetes