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While both promote neural repair, they engage entirely different growth factor systems

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The clinical research currently consists of the following: Small 1980s pilot trials No large modern RCTs Limited pharmacokinetic clarity No validated subcutaneous dosing protocol for improved sleep DSIP likely works for many individuals, but its critical to acknowledge the doses used by the biohacking community comes from extrapolation

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Then, in 2015, Lee and colleagues identified a previously overlooked open reading frame within the 12S ribosomal RNA gene of mtDNA and found that it encodes a functional peptide, MOTS-c (Mitochondrial Open Reading Frame of the 12S rRNA-c) [1]