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If you experience any unexpected symptoms whilst participating in a trial, you should: Contact your trial coordinator immediately, as trial participants must report adverse events through their study team Report suspected side effects via the MHRA Yellow Card scheme at yellowcard.mhra.gov.uk if appropriate Seek urgent medical attention if symptoms are severe Current Availability and Regulatory Status in the UK Neither cagrilintide nor retatrutide holds MHRA marketing authorisation in the UK

Watch for irritation, but also note any positive changes like improved hydration or skin feel