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Deficiency can lead to macrocytic anaemia, neurological symptoms including peripheral neuropathy, cognitive changes, and fatigue
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] 5-Amino-1MQ (5-amino-1-methylquinolinium) has gained significant attention in metabolic research and clinical applications
These are potent pharmaceutical agents, not supplements, and medical oversight improves both safety and outcomes
However, there is no scientific evidence supporting B12 supplementation for direct fat loss in individuals with normal B12 levels
One study in diet-induced obese mice found that an NNMT inhibitor combined with a calorie-restricted diet was associated with shifts in gut bacterial populations, suggesting metabolic intervention can have knock-on effects on gut composition
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