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Glutathione synthesis is usually suboptimal in folks with type 2 diabetes

This is another reason aliquoting into smaller vials makes sense for multi-week protocols

Kumar K, Woo SM, Siu T, Cortopassi WA, Duarte F, Paton RS

In one mouse study, researchers found that the peptide reduced the pain felt by the animals in their paws when placed on a mildly hot plate. The authors explained that this could be because GHK is similar in structure to cimetidine, a histamine H2 receptor antagonist sometimes given to reduce pain in certain digestive conditions.3 10 In rodents, doses as low as 0.5mg/kg were found to be effective in delivering these anti-pain effects.25 In a 70kg human, an equivalent dose would be around 5.6mg, though thats likely higher than necessary: pharmaceutical-grade GHK-Cu normally ranges from 0.5 mg to 2.5mg per injection

[PMID: 11384612] PubMed record related to this compound for laboratory literature review

Thus, timing also holds significance in optimizing effectiveness