There is a company currently called Agentix that is investigating a new CB1 receptor antagonist as an antiobesity drug and, very unfortunately, its OTC and only has a market cap of 3 million or else this entire article would be about why everyone should short it
Still, evidence for pain relief in humans remains limited
A pilot study published in the European Journal of Clinical Nutrition provided evidence that oral supplementation with liposomal glutathione elevates body stores of glutathione and markers of immune function
Among the tested interventions, Bifidobacterium infantis produced the most pronounced effects, showing the greatest reduction in gut-leakiness markers and the strongest upregulation of GABA-receptor expression (Zarezadeh et al., 2023)
Use a fresh needle every time, as reused needles develop microscopic burrs that tear tissue rather than puncturing cleanly
Finding the right GLP-1 tracking app can make the difference between a stop-and-start routine and steady, lasting progress