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Rapid fat loss may affect how thyroid hormones are metabolized, possibly leading to changes in TSH and T4 levels

10.1016/j.bbrc.2009.01.003

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Esto puede causar lipohipertrofia (acumulacin de tejido graso) o lipoatrofia (prdida de tejido graso), alterando la absorcin del medicamento y creando irregularidades visibles en la piel

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For example, these factors lower the threshold for clot formation: Coronary artery disease with plaque Diabetic vascular disease Chronic inflammatory disorders Prior thrombosis Dehydration, immobilization after surgery, or the combined use of drugs that affect clotting can further increase risk