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These drugs have also been shown to reduce haemoglobin A1c levels, support weight loss and lower the risk of cardiovascular events by mimicking the GLP-1 hormone.
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Oral semaglutide produced a 1.2% A1C reduction and 5.0 kg weight loss, which was superior to placebo and noninferior to liraglutide 2
This heterogeneity may be attributed to differences in baseline HbA1c levels, obesity prevalence, trial duration, comparator treatments, dosing strategies, and outcome definitions
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