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Specifically, knocking out NCOA4 in cardiomyocytes alleviates heart failure caused by transection aortic contraction (TAC) by inhibiting ferritinophagy, free iron overload, and increased lipid peroxidation

Banerjee A, Roychoudhury A (2016) Group II late embryogenesis abundant (LEA) proteins: structural and functional aspects in plant abiotic stress

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Importantly, these implications were observed without direct immunosuppression of specific cytokines such as TNF, implying a more regulatory mode of action