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Consistent with these findings, H&E staining of liver sections revealed significant lipid accumulation in SKO mice that was considerably reduced by liraglutide treatment in female SKO mice ( Figure 3C ) but this was not evident in liraglutide-treated male SKO mice ( Figure 3D )

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Subsequently, the signal is transferred to collapsin response mediator protein 2 (CRMP2) that regulates cytoskeletal organization and thereby axonal outgrowth/repulsion