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2+ channels in VSMCs (Smith et al., 2020), triggering depolarizing Ca 2+ spikes in VSMCs leading to vasoconstriction (Ng et al., 2024)

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Proposed axes such as lung-heart ferroptotic coupling are intriguing but currently rest largely on correlative in vivo imaging, inflammatory signaling, and systemic oxidative stress markers rather than direct causal relay experiments

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Answer: The most common side effects of amylin analogs are gastrointestinal, including nausea, reduced appetite, and occasional vomiting or constipation, and they are usually mild, dose-related, and managed by slow titration

Cirrhosis Acute liver failure Liver failure Severe inability of the liver to perform its normal metabolic functions, as evidenced by severe jaundice and abnormal serum levels of ammonia