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The first animal studies showing that GLP-1 potentially had effects on the CV system was published in 2002, and the first study to show cardioprotection was in 2008 (102, 211), but it was not until the LEADER cardiovascular outcomes trial (CVOT) with liraglutide, published in 2016, that a reduction in CV risk with a GLP-1RA was documented (100)

Microdosing refers to taking far smaller doses than those set out by standard medical guidelines

Potential drug interactions have not been systematically studied

Efficacy of lactoferrin oral administration in the treatment of anemia and anemia of inflammation in pregnant and non-pregnant women: an interventional study

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Starting with very small doses (0.05 - 0.10 mg) can reduce nausea and digestive side effects