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In line with the covalent binding mechanism, in vitro and cell-based thermal-shift assays showed that C1-27 induced a negative shift in the melting temperature indicating protein destabilization on binding (Supplementary Figs 11 and 15)
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This work was supported by grant from National Natural Science Foundation of China (81570013)
European Journal of Endocrinology , 139(5), 552561
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