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The Importance of Medical Supervision Although both semaglutide and L-carnitine offer significant benefits, they should always be used under the guidance of trained medical professionals

In the interim, continued shared decision making with patients and clinical vigilance for pancreatic diseases in patients on GLP-1RA therapy remains prudent

Cell Mol Biol Lett 30 , 147 (2025)

Abbreviations Alb: Albumin ANCOVA: Analysis of covariance APACHE II: Acute physiology and chronic health evaluation II Bil-D: Direct bilirubin Bill-T: Total bilirubin BMI: Body mass index BUN: Blood urea nitrogen CAT: Catalase CBC: Complete blood count Cl: Chloride Cr: Creatinine CRP: C-reactive protein DBP: Diastolic blood pressure ESR: Erythrocyte sedimentation rate GR: Glutathione reductase GSH: Glutathione GSH-Px: Glutathione-peroxidase ICU: Intensive care unit IL-6: Interleukin-6 iNOS: Induced nitric oxide synthase ITT: Intention-to-treat LC: L-carnitine MCH: Mean corpuscular volume MCHC: Mean corpuscular volume concentration MDA: Malondialdehyde NADPH-oxidase: Nicotinamide-adenine-dinucleotide phosphate-oxidase Nrf2: Nuclear-factor-erythroid-2-related-factor-2 NF-kB: Nuclear factor kappa B NO: Nitric oxide NUTRIC: Nutrition risk in the critically ill PAMPs: Pathogen-associated molecular patterns Plt: Platelet PO 2 : Blood pressure of oxygen PPAR: Peroxisome-proliferator activated-receptor PT: Prothrombin time PTT: Partial prothrombin time qSOFA: Quick SOFA RNS: Reactive nitrogen species ROS: Reactive oxygen species SBP: Systolic blood pressure SCCM: Society of critical care medicine SD: Standard deviation SOD: Superoxide dismutase SOFA: Sequential organ failure assessment TAC: Total antioxidant capacity TNF-: Tumor necrosis factor- WBC: White blood cell XO: Xanthine-oxidase References Huang M, Cai S, Su J

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