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Key Facts Although the drugs were first approved for Type 2 diabetes maintenance, they were approved for weight loss in recent years, and research has shown they cause significant results: Tirzepatide typically causes patients to lose an average of 22.5% of body fat, while semaglutide causes a 15% reduction
Not for use on broken, infected, or actively inflamed skin without professional assessment
Semaglutide starts work by simulating GLP-1 hormone, increasing secretion of insulin, inhibiting glucagon release, overpowering appetite, gastric activity also slow down and leading to better glucose control and weight loss
The long half-life is driven by albumin binding (greater than 99% bound), reduced DPP-4 degradation due to the Aib8 substitution, and slowed renal clearance of the larger albumin-bound complex
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Skin-colored or pink millimetric papules or tumors located in periungual or subungual areas
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