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To sidestep this side effect, Criner recommends aiming for more-gradual weight loss, eating a protein-rich diet, and staying hydrated
Of the patients who switched medications, 8 in 10 switched to AOM semaglutide
The STEP-4 trial demonstrated that patients who switched from semaglutide to placebo after 20 weeks regained roughly two-thirds of their lost weight within a year [9]
It is reprioritization
A review published in Trends in Cardiovascular Medicine found that monthly lifestyle counseling visits improved adherence and weight loss outcomes at 68 weeks.10 Interestingly, individuals who followed a more intensive, nonpharmacologic plan (including meal replacements and behavioral therapy) achieved similar weight loss results at 68 weeks compared with those using injectables.10 These findings further highlight the value of consistent, structured nutrition counseling in promoting sustainable weight management
Cardiovascular and kidney-LEADER, Sustain-6, REWIND, SELECT, FLOW Cognitive-Wang 2024, Gejl 2016, Athauda 2017 Inflammation-Ren 2025, Mason 2024 Liver-Arun 2025, Newsome 2021 Begin your journey Weight gain in midlife isnt just a fact of life
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