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There are also ethical and societal questions
Researchers said weight regain has been reported after stopping other obesity medications, and overall data confirm the chronicity of obesity and highlight the importance of maintaining long-term pharmacological treatment for weight management in people with obesity. The success of GLP-1 medications can depend on how long people use them
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10.1016/S0002-9440(10)63877-1 4 BaiT.LiangB.ZhaoY.HanJ.PuY.WangC.et al (2022)
The binding affinity is so strong that the copper remains complexed with the peptide during transport and only releases at the appropriate enzymatic sites
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