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A total of 577 patients were randomly assigned (1:1:1) to receive once-weekly dulaglutide (1.5 mg), once-weekly dulaglutide (0.75 mg), or daily insulin glargine as basal therapy, all in combination with insulin lispro, for 52 weeks

Treatment typically begins at a lower starting dose, which is gradually adjusted under medical supervision to reduce side effects and support safe progress

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doi:10.1371/journal.pmed.1004039

Electrolytes become especially important if nausea or reduced food intake leads to mineral loss

G., Brooks, L., Bewick, G