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The Effects of Growth Hormone Receptor on Mitochondrial Biogenesis In recent decades, genetically engineered mouse strains ( GHR gene disrupted or knockout mouse) have become vital tools for exploring the various activities of GH and GHR in vivo ( GHR gene mutations, also allows this strain to become a model system to understand the roles of GHR in vivo ( Early in the 21st century, GHR is considered to exhibit a negative effect on the process of mitochondrial biogenesis in vivo

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