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These findings suggest that GLP-1 and its metabolites might modulate TRPV1 activity, which plays a pivotal role in heat pain perception 19,49
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The omega-3 fatty acids docosahexaenoic acid and eicosapentaenoic acid serve a role in reducing the resistance of tumor cells to bortezomib by activating the serine synthesis pathway, mitochondrial folate cycle, methionine cycle-associated GSH synthesis and ChaC1-mediated GSH degradation in tumor cells, ultimately promoting GSH degradation (138)
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