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Adverse effects were uncommon and mild (10 patients) and resolved after discontinuation

It follows a once-weekly injection schedule with a gradual step-up approach, starting low and increasing every few weeks to help your body adjust

Hassan SMA et al

Staying hydrated helps reduce potential side effects like headaches or fatigue

Moreover, metformin stimulates GLP-1R and PKA signalling via AMPK-dependent pathway, which may account for its synergistic protective effects with liraglutide

This functionalization enables cartilage-targeted delivery, allowing for selective enrichment of GLP-1RAs at diseased joint sites and facilitating precise therapeutic intervention