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Key Things We Consider Initial metabolic levels and body composition Previous use of appetite-related medications Sensitivity to digestion changes when starting treatment Weekly appetite shifts Goals for the long run and when to expect results Starting with smaller doses helps the body adapt over time

Hanno et al., 2011)

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35 Inappropriate Combination of GLP-1 RA The American Diabetes Association (ADA) and the American Association of Clinical Endocrinologists advocate for the use of GLP-1 RA as supplementary therapy in combination with oral agents and insulin but advise against concomitant use with DPP4 inhibitors due to limited evidence

In a trial of 3,297 patients, most of whom had preexisting retinopathy, diabetic retinopathy complications occurred in 3% of those taking semaglutide vs

A summary of clinically-significant GLP-1RAs described in this text and their clinical uses are listed in Table 1